Gigi Phillips (Ginnifer Goodwin) was named after writer Marc Silverstein's wife, Busy Phillips and her baby blanket ("Gigi").
Jennifer Connelly plays a character whose father died of cancer. In real life, her actual father was dying of cancer at the time, and passed before this film was released.
Theresa Russell filmed two scenes as Anna's (Scarlett Johansson's) mother Maya, but both scenes were deleted from the final film. These scenes are available on the DVD's special features.
When Gigi (Ginnifer Goodwin) is home and her phone rings, the movie she is watching is Some Kind of Wonderful (1987), also about relationships and the complications the characters entail.
Shipped to theaters under the code name "Boy Trouble".